Integrated Granulation Line: A Complete Solution for Oral Solid Dosage Manufacturing

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 · 
Marzo 26, 2026
 · 
3 min read
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In today’s pharmaceutical landscape, efficiency, repeatability, and compliance are essential. Manufacturers are increasingly looking for partners capable to deliver not just individual machines, but fully integrated granulation line solutions in order to optimize the entire production process.

This is exactly where Nicomac positions itself: as a single, qualified supplier for complete Oral Solid Dosage (OSD) lines, covering every phase from granulation to coating, with a strong focus on engineering, integration, and process performance.

Granulation Line: A Fully Integrated Approach

Nicomac designs, manufactures, installs, and validates complete granulation and coating lines, ensuring seamless interaction between all process steps.

From raw material handling to final coating, every component is engineered to work as part of a unified system:

  • High Shear Mixers for efficient and homogeneous wet granulation
  • Fluid Bed systems for drying, granulation, and coating
  • Lifters and handling systems for safe and contained material transfer
  • Bin Blenders for uniform powder mixing
  • Conical Mills for precise particle size control
  • Tablet Presses for high-efficiency compression (made with a trusted partner)
  • Perforated and Solid Coating Pans for advanced coating applications
  • Easy Coater solutions for compact and flexible installations

This integrated philosophy allows Nicomac to provide either single equipment or complete turnkey systems, based on horizontal or vertical process layouts .

Engineering Excellence and Process Optimization

At the core of Nicomac’s offering lies a strong engineering approach. Each solution is highly customized, adapting to product characteristics, process requirements, and facility constraints. The relationship with the customer evolves from a simple supplier-client interaction into a true partnership, built on listening, consultancy, and the ability to tailor production to specific needs.

These optimizations translate directly into higher product quality, improved batch consistency, and reduced production costs.

Automation, Compliance, and Repeatability

Modern pharmaceutical production requires strict adherence to GMP standards and full process traceability. Nicomac addresses these needs through advanced automation and control systems.

All equipment is managed via PLC-PC platforms, enabling:

  • fully automated process cycles
  • precise control of critical parameters
  • integration of washing (WIP/CIP) procedures
  • high reproducibility and reduced operator intervention

Additionally, systems are designed with GMP-compliant construction, easy cleaning, and minimal product retention, ensuring maximum safety and efficiency.

Flexibility from R&D to Industrial Scale

One of the key strengths of Nicomac solutions is their scalability. The company supports customers across the entire product lifecycle, from early-stage development to full-scale production.

  • Lab-scale equipment allows testing and formulation development starting from small batch sizes
  • Modular designs enable smooth scale-up without compromising process parameters
  • High-capacity production systems ensure efficiency for industrial manufacturing

This flexibility is particularly valuable in an industry where speed-to-market and adaptability are critical success factors.

Coating Technologies at the Forefront

Nicomac’s coating solutions represent the latest evolution in pharmaceutical coating technology, ensuring uniform coating, reduced product loss, and high process efficiency. Our coating pans (PSC Perforated Super Coater; SWC Solid Wall Coater; Easy Coater) are capable of handling:

  • film coating
  • sugar coating
  • enteric and modified release applications
  • pelletizing processes

Advanced features such as:

  • optimized airflow distribution
  • precision spray systems
  • real-time temperature control

High-Containment and Advanced Solutions

For highly potent compounds, Nicomac provides integrated high-containment lines capable of operating at OEB3 to OEB5 levels, ensuring operator safety and product protection.

All integrated within the same process philosophy, maintaining consistency and performance across the entire line.

One Partner, One Responsibility

Choosing Nicomac means relying on a partner that takes full responsibility for the entire process.

From initial design to installation and validation, customers benefit from:

  • a single point of contact
  • reduced project complexity
  • guaranteed system integration
  • faster commissioning and time-to-production
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